2024

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Patel R, Taylor JL, Dickenson AH, McMahon SB, Bannister K. A back-translational study of descending interactions with the induction of hyperalgesia by high frequency electrical stimulation in rat and human. Pain 2024; (online ahead of print). doi: 10.1097/j.pain.0000000000003166

 

2023

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Patel R. The circuit basis for chronic pain and its co-morbidities. Current Opinion in Supportive & Palliative Care 2023; 17(3):156-160. doi: 10.1097/SPC.0000000000000650

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Nieto-Rostro M, Patel R, Dickenson AH, Dolphin AC. Nerve injury increases native CaV2.2 trafficking in dorsal root ganglion mechanoreceptors. Pain 2023; 164(6):1264-1279. doi: 10.1097/j.pain.0000000000002846

 

2022

 

Trendafilova T, Adhikari K, Schmid AB, Patel R, Polgár E, Boyle KA, Dickie AC, Bell AM, Ramirez-Aristeguieta LM, Khoury S, Ivanov A, et al,. Sodium-Calcium Exchanger-3 Regulates Pain ‘Wind-Up’: From Human Psychophysics to Spinal Mechanisms. Neuron 2022; 110(16):2571-2587.e13. doi:10.1016/j.neuron.2022.05.017

 

Patel R, Dickenson AH, Argoff CE. Chapter 53 Anti-depressants. Practical Management of Pain, 6th Edition, Pages 743-751. Elsevier 2022 ISBN 9780323711012

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Patel R & Dickenson AH. Neuropharmacological basis for multimodal analgesia in chronic pain. Postgraduate Medicine 2022;134(3):245-259. doi: 10.1080/00325481.2021.1985351

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2021

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Patel R, Lumb BM, Bannister K. Editorial: Plasticity of Endogenous Pain Modulatory Circuits in Neuropathy. Frontiers in Pain Research 2021;2:776948. doi: 10.3389/fpain.2021.776948

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Peck LJ, Patel R, Diaz P, Wintle YM, Dickenson AH, Todd AJ, Calvo M, Bennett DLH. Studying independent Kcna6 knock-out mice reveals toxicity of exogenous LacZ to central nociceptor terminals and differential effects of Kv1.6 on acute and neuropathic pain sensation. The Journal of Neuroscience 2021; 41(44): 9141-9162. doi: 10.1523/JNEUROSCI.0187-21.2021

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2020

 

Yosten GLC, Harada CM, Haddock CJ, Giancotti LA, Kolar GR, Patel R, Guo C, Chen Z, Zhang J, Doyle TM, et al. GPR160 de-orphanization reveals critical roles in neuropathic pain in rodents. The Journal of Clinical Investigation 2020;130(5):2587-92. doi: 10.1172/JCI133270

 

Patel R, Dickenson AH. A study of cortical and brainstem mechanisms of diffuse noxious inhibitory controls in anaesthetised normal and neuropathic rats. The European Journal of Neuroscience 2020;51(4):952-62. doi: 10.1111/ejn.14576

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Dickenson AH, Patel R. Translational issues in precision medicine in neuropathic pain. Canadian Journal of Pain 2020;4(1):30-8.

doi: 10.1080/24740527.2020.1720502

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Dickenson AH, Navratilova E, Patel R, Porreca F, Bannister K. Supraspinal Opioid Circuits Differentially Modulate Spinal Neuronal Responses in Neuropathic Rats. Anesthesiology 2020;132(4):881-94. doi: 10.1097/ALN.0000000000003120

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2019

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Patel R, Kucharczyk M, Montagut-Bordas C, Lockwood S, Dickenson AH. Neuropathy following spinal nerve injury shares features with the irritable nociceptor phenotype: A back-translational study of oxcarbazepine. European Journal of Pain 2019;23(1):183-97. doi: 10.1002/ejp.1300

(Winner of European Pain Federation award for best basic research paper 2017/18))

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2018

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Patel R, Qu C, Xie JY, Porreca F, Dickenson AH. Selective deficiencies in descending inhibitory modulation in neuropathic rats: implications for enhancing noradrenergic tone. Pain 2018;159(9):1887–99. doi: 10.1097/j.pain.0000000000001300

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Patel R, Montagut-Bordas C, Dickenson AH. Calcium channel modulation as a target in chronic pain control. British Journal of Pharmacology 2018;175(12):2173-84. doi: 10.1111/bph.13789

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Patel R, Dickenson AH. Modality selective roles of pro-nociceptive spinal 5-HT2A and 5-HT3 receptors in normal and neuropathic states. Neuropharmacology 2018;143:29-37. doi: 10.1016/j.neuropharm.2018.09.028

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Dickenson AH, Patel R. Sense and sensibility-logical approaches to profiling in animal models. Pain 2018;159(7):1426-8. doi:10.1097/j.pain.0000000000001245

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Dawes JM, Weir GA, Middleton SJ, Patel R, Chisholm KI, Pettingill P, Peck LJ, Sheridan J, Shakir A, Jacobson L, et al. Immune or Genetic-Mediated Disruption of CASPR2 Causes Pain Hypersensitivity Due to Enhanced Primary Afferent Excitability. Neuron 2018;97(4):806-22 e10. doi: 10.1016/j.neuron.2018.01.033

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Durkin EJ, Muessig L, Herlt T, Lumb MJ, Patel R, Thomas P, Bright DP, Jurd R, Moss SJ, Dickenson AH, Cacucci F, Smart TG. Brain neurosteroids are natural anxiolytics targeting α2 subunit γ-aminobutyric acid type-A receptors. bioRxiv 2018; 462457:1-46. doi: 10.1101/462457

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2017

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Dalmolin GD, Bannister K, Goncalves L, Sikandar S, Patel R, Cordeiro MDN, Gomez MV, Ferreira J, Dickenson AH. Effect of the spider toxin Tx3-3 on spinal processing of sensory information in naive and neuropathic rats: an in vivo electrophysiological study. Pain Reports 2017;2(4):e610. doi: 10.1097/PR9.0000000000000610

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Bannister K, Lockwood S, Goncalves L, Patel R, Dickenson AH. An investigation into the inhibitory function of serotonin in diffuse noxious inhibitory controls in the neuropathic rat. European Journal of Pain 2017;21(4):750-60. doi: 10.1002/ejp.979

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2016

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Patel R, Dickenson AH. Neuronal hyperexcitability in the ventral posterior thalamus of neuropathic rats: modality selective effects of pregabalin. Journal of Neurophysiology 2016;116(1):159-70. doi: 10.1152/jn.00237.2016

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Patel R, Dickenson AH. Mechanisms of the gabapentinoids and alpha 2 delta-1 calcium channel subunit in neuropathic pain. Pharmacology Research Perspectives 2016;4(2):e00205. doi: 10.1002/prp2.205

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2015

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Rahman W, Patel R, Dickenson AH. Electrophysiological evidence for voltage-gated calcium channel 2 (Cav2) modulation of mechano- and thermosensitive spinal neuronal responses in a rat model of osteoarthritis. Neuroscience 2015;305:76-85. doi: 10.1016/j.neuroscience.2015.07.073

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Patel R, Rutten K, Valdor M, Schiene K, Wigge S, Schunk S, Damann N, Christoph T, Dickenson AH. Electrophysiological characterization of activation state-dependent Ca(v)2 channel antagonist TROX-1 in spinal nerve injured rats. Neuroscience 2015;297:47-57. doi: 10.1016/j.neuroscience.2015.03.057

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Patel R, Brice NL, Lewis RJ, Dickenson AH. Ionic mechanisms of spinal neuronal cold hypersensitivity in ciguatera. The European Journal of Neuroscience 2015;42(11):3004-11. doi: 10.1111/ejn.13098

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Falk S, Patel R, Heegaard A, Mercadante S, Dickenson AH. Spinal neuronal correlates of tapentadol analgesia in cancer pain: a back-translational approach. European Journal of Pain 2015;19(2):152-8. doi: 10.1002/ejp.530

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Bannister K, Patel R, Goncalves L, Townson L, Dickenson AH. Diffuse noxious inhibitory controls and nerve injury: restoring an imbalance between descending monoamine inhibitions and facilitations. Pain 2015;156(9):1803-11. doi: 10.1097/j.pain.0000000000000240

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2014

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Patel R, Goncalves L, Newman R, Jiang FL, Goldby A, Reeve J, Hendrick A, Teall M, Hannah D, Almond S, et al. Novel TRPM8 antagonist attenuates cold hypersensitivity after peripheral nerve injury in rats. The Journal of Pharmacology and Experimental Therapeutics 2014;349(1):47-55. doi: 10.1124/jpet.113.211243

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Patel R, Goncalves L, Leveridge M, Mack SR, Hendrick A, Brice NL, Dickenson AH. Anti-hyperalgesic effects of a novel TRPM8 agonist in neuropathic rats: a comparison with topical menthol. Pain 2014;155(10):2097-107. doi: 10.1016/j.pain.2014.07.022

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2013

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Sikandar S, Patel R, Patel S, Sikander S, Bennett DL, Dickenson AH. Genes, molecules and patients--emerging topics to guide clinical pain research. European Journal of Pharmacology 2013;716(1-3):188-202. doi: 10.1016/j.ejphar.2013.01.069

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Patel R, Bauer CS, Nieto-Rostro M, Margas W, Ferron L, Chaggar K, Crews K, Ramirez JD, Bennett DL, Schwartz A, et al. alpha2delta-1 gene deletion affects somatosensory neuron function and delays mechanical hypersensitivity in response to peripheral nerve damage. The Journal of Neuroscience 2013;33(42):16412-26. doi: 10.1523/JNEUROSCI.1026-13.2013

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2010

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Papadopoulos D, Rundle J, Patel R, Marshall I, Stretton J, Eaton R, Richardson JC, Gonzalez MI, Philpott KL, Reynolds R. FTY720 ameliorates MOG-induced experimental autoimmune encephalomyelitis by suppressing both cellular and humoral immune responses. Journal of Neuroscience Research 2010;88(2):346-59. doi: 10.1002/jnr.22196

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2009

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Papadopoulos D, Dukes S, Patel R, Nicholas R, Vora A, Reynolds R. Substantial archaeocortical atrophy and neuronal loss in multiple sclerosis. Brain Pathology 2009;19(2):238-53. doi: 10.1111/j.1750-3639.2008.00177.x